TITLE: Detection of human T-cell leukemia/lymphoma virus type I in a transfusion recipient with chronic myelopathy.
AUTHORS: Saxton EH; Lee H; Swanson P; Chen IS; Ruland C Chin E; Aboulafia D; Delamarter R; Rosenblatt JD
ABSTRACT: A white man with a progressive spastic paraparesis that began 15 months after sustaining severe trauma in a motor vehicle accident was positive for antibodies to human T-lymphotropic virus type I (HTLV-I) by enzyme-linked immunosorbent assay. Serum antibody to HTLV-I was confirmed by Western blot and radioimmunoprecipitation assay. We detected specific proviral DNA in peripheral blood lymphocytes by the polymerase chain reaction. Because the incidence of HTLV-I is generally restricted to Southern Japan and Caribbean black populations, the most likely source of HTLV-I infection in this patient was multiple intraoperative blood transfusions. The relatively short interval between transfusion and development of HTLV-I-associated myelopathy is consistent with the more rapid evolution of this clinical syndrome compared with adult T-cell leukemia.
SOURCE: Neurology 1989 Jun;39(6):841-4