||Detection of human T-cell leukemia/lymphoma
virus type I in a transfusion recipient with chronic myelopathy.
||Saxton EH; Lee H; Swanson P; Chen IS; Ruland
C Chin E; Aboulafia D; Delamarter R; Rosenblatt JD
||A white man with a progressive spastic paraparesis
that began 15 months after sustaining severe trauma in a motor vehicle accident
was positive for antibodies to human T-lymphotropic virus type I (HTLV-I)
by enzyme-linked immunosorbent assay. Serum antibody to HTLV-I was confirmed
by Western blot and radioimmunoprecipitation assay. We detected specific
proviral DNA in peripheral blood lymphocytes by the polymerase chain reaction.
Because the incidence of HTLV-I is generally restricted to Southern Japan
and Caribbean black populations, the most likely source of HTLV-I infection
in this patient was multiple intraoperative blood transfusions. The relatively
short interval between transfusion and development of HTLV-I-associated
myelopathy is consistent with the more rapid evolution of this clinical
syndrome compared with adult T-cell leukemia.
||Neurology 1989 Jun;39(6):841-4